The International Space Station (ISS) orbits 400km above our heads. It has been permanently inhabited by astronauts since 2000 and, as our outpost in space, it is a habitat, laboratory and research station all in one. The experiments conducted on the space station are diverse and range from questions of medicine and biology, material sciences and physics, the study of the Earth and its climate, to questions of the Sun and the planets in the solar system, and out into the astronomical expanses of the cosmos. The keynote lecture gives an insight into the weightless life and research of astronauts on the ISS.