Cancer is the second leading cause of death. One of its main characteristics is that cells of a person’s body start dividing continuously, refusing to stop. Our immune system is constantly on the watch for cells that behave out of order, a process called, “immune surveillance.” Immune Checkpoints are cell-surface proteins shutting down immune responses.
Some cancers have adapted to display checkpoints to stop immune cells from killing. Through visualizing the trajectories of cell states of different time states the immune cell’s gene activity can be observed to help understand the mechanisms behind this disease and identify novel treatment targets for future medical applications.